Search results
Search for "telescoped process" in Full Text gives 6 result(s) in Beilstein Journal of Organic Chemistry.
Inline purification in continuous flow synthesis – opportunities and challenges
Beilstein J. Org. Chem. 2022, 18, 1720–1740, doi:10.3762/bjoc.18.182
- separation using a computer-vision approach. Redrawn from [68]. Example of an inline purification using heterogeneous scavenging. Redrawn from [76]. General scheme of a telescoped process using heterogenous cartridges. Comparison of two strategies for flow-based imatinib syntheses. Redrawn from [91] and [92
- that combines several unit operations is targeted [31][32][33]. This is always a challenging undertaking as decisions on solvents, concentrations and preferred reagents and reaction conditions (e.g., thermal, photo- or electrochemical, biocatalyzed) will inevitably affect the resulting telescoped
- process. One question which is thereby of great importance is whether inline purification is required to improve the overall process. This is an important question as the removal of impurities and spent reagents typically facilitates subsequent chemical reactions in a telescoped multistep sequence. In
Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives
Beilstein J. Org. Chem. 2021, 17, 379–384, doi:10.3762/bjoc.17.33
- within continuous flow processes [17][18][19][20] to provide a greener and more chemoselective means for the synthesis of drug-like targets. Recently, we reported on an innovative telescoped process using immobilized CALB (Candida antarctica lipase B) to enable the conversion of residual benzyl alcohol
High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine
Beilstein J. Org. Chem. 2018, 14, 583–592, doi:10.3762/bjoc.14.45
- catalyst in a continuous stirring tank reactor (CSTR) for the synthesis of compound 12, and have incorporated it into a fully continuous telescoped process for the synthesis of 12 from lactone 8 and aminoethanol 7. Feeding the output stream containing 12 from the above CSTR into a second CSTR in which 12
- -line extraction of 10. Optimization of the flow process for the synthesis of 12. Optimization of the flow process for the synthesis of 10. Schematic representation for the continuous telescoped process to synthesize 11. Optimization of the flow process for the reductive amination of 12 using a CSTR
An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles
Beilstein J. Org. Chem. 2013, 9, 2265–2319, doi:10.3762/bjoc.9.265
- protonation steps. This is followed by Boc-protection and interconversion of the ethyl ester to its amide derivative 2.82 in 80% overall yield for this telescoped process. The primary amide in 2.82 was then oxidised via a modern variant of the classical Hoffmann rearrangement using phenyliodine diacetate
Controlled synthesis of poly(3-hexylthiophene) in continuous flow
Beilstein J. Org. Chem. 2013, 9, 1492–1500, doi:10.3762/bjoc.9.170
- reaction temperatures used. To demonstrate the flow synthesis of P3HT from 2,5-dibromo-3-hexylthiophene (1), the Grignard metathesis step was performed in the tube reactor followed by the addition of the Ni(dppp)Cl2 catalyst for the polymerization (Scheme 2). In this telescoped process, the thiophene
Development of an additive-controlled, SmI2-mediated stereoselective sequence: Telescoped spirocyclisation, lactone reduction and Peterson elimination
Beilstein J. Org. Chem. 2013, 9, 1443–1447, doi:10.3762/bjoc.9.163
- Peterson elimination. The approach allows functionalised cyclopentanols containing two vicinal quaternary stereocentres to be conveniently prepared from simple starting materials. Keywords: cyclisation; free radical; Peterson elimination; reduction; samarium; telescoped process; Introduction Samarium
Other Beilstein-Institut Open Science Activities
